Membrane trafficking: vesicle formation, cargo sorting and fusion
نویسندگان
چکیده
منابع مشابه
Theory of cargo and membrane trafficking
Endocytosis underlies many cellular functions including signaling and nutrient uptake. The endocytosed cargo gets redistributed across a dynamic network of endosomes undergoing fusion and fission. Here, a theoretical approach is reviewed which can explain how the microscopic properties of endosome interactions cause the emergent macroscopic properties of cargo trafficking in the endosomal netwo...
متن کاملESCRT-II coordinates the assembly of ESCRT-III filaments for cargo sorting and MVB vesicle formation
As you will see from their comments the referees express interest in the role of Vps25 in activating Vps20 and the requirement of two Snf7 oligomers for cargo sorting and request some further experimental analysis to make the study suitable for publication in the EMBO Journal. All the referees would like to see some further evidence for Snf7 oligomerisation in determining vesicle size, referee ...
متن کاملARFGAP1 plays a central role in coupling COPI cargo sorting with vesicle formation
Examining how key components of coat protein I (COPI) transport participate in cargo sorting, we find that, instead of ADP ribosylation factor 1 (ARF1), its GTPase-activating protein (GAP) plays a direct role in promoting the binding of cargo proteins by coatomer (the core COPI complex). Activated ARF1 binds selectively to SNARE cargo proteins, with this binding likely to represent at least a m...
متن کاملVesicle trafficking and membrane remodelling in cytokinesis.
All cells complete cell division by the process of cytokinesis. At the end of mitosis, eukaryotic cells accurately mark the site of division between the replicated genetic material and assemble a contractile ring comprised of myosin II, actin filaments and other proteins, which is attached to the plasma membrane. The myosin-actin interaction drives constriction of the contractile ring, forming ...
متن کاملSuzanne Pfeffer: Sorting through membrane trafficking
S uzanne Pfeffer always wanted to know what makes the human body tick. In many respects, we're still working on deciphering the fi rst page of the body's operating manual—which Pfeffer says is fi ne, since it means there's plenty of room for new discoveries. Pfeffer had her fi rst publication as an undergraduate at UC Berkeley (1), which got her hooked on the spirit of scientifi c inquiry. Foll...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Biology of the Cell
سال: 2020
ISSN: 1059-1524,1939-4586
DOI: 10.1091/mbc.e19-12-0680